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Research Article

Effect of pyruvate supplementation on growth performance, blood profile and antioxidant activity in broilers fed high oxalate diets
Won-Vin Choi1†
,
Gyu-Seong Kim1†
,
Min-Ju Kim12*
1School of Animal Life Science, Hankyong National University, Anseong 17579, Republic of Korea
2Institute of Applied Humanimal Science, Hankyong National University, Anseong 17579, Republic of Korea
*Corresponding Author
†These authors contributed equally to this work.
30 June 2025. pp. 68-76
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Abstract

This study was conducted to investigate the effects of pyruvate supplementation in mitigating the anti-nutritional effects of oxalate on growth performance, blood profiles, and antioxidant activity in broilers. A total of 216 broiler chicks (d 1, Ross 308) were randomly assigned to three treatments based on initial body weight. Each treatment consisted of 12 replicates with 6 birds per replicate, and the experiment lasted for 42 days. The dietary treatments included a control diet (CON), a diet supplemented with 1% oxalate (Ox), and a diet supplemented with 1% oxalate and 1% pyruvate (OxPyr). Blood samples were collected from the wing vein of one randomly selected bird per pen. Body weight gain was significantly higher in the CON group compared to the Ox and OxPyr groups during phases 1 to 3, and the Ox group had the lowest BWG throughout the experimental period (p < 0.05). Feed intake was significantly higher in the CON group than in the Ox and OxPyr groups, while feed conversion ratio did not differ significantly among the treatments. Serum AST concentration was significantly higher in the Ox group, and cortisol concentration was significantly lower in the OxPyr group. The concentration of GSTs was significantly higher in the CON group, while the concentrations of GSH-Px, SOD, and T-AOC were significantly higher in the Ox group than in the CON and OxPyr groups (p < 0.05). These results suggest that pyruvate supplementation with a high-oxalate diet mitigates the anti- nutritional effects of oxalate on blood profiles and antioxidant enzyme levels.

Keywords
Anti-nutritional factors
Antioxidant
Broiler
Oxalate
Pyruvate
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Information
  • Publisher :Journal of Humanimal Sciences
  • Publisher(Ko) :한경국립대학교 휴머니멀응용과학연구소
  • Journal Title :Journal of Humanimal Sciences
  • Journal Title(Ko) :휴머니멀과학학술지
  • Volume : 1
  • No :2
  • Pages :68-76
  • Received Date : 2025-05-21
  • Revised Date : 2025-05-30
  • Accepted Date : 2025-06-03
  • DOI :https://doi.org/10.23341/jhas.2025.1.2.68
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